News

Gauss Lecture given by Prof. Wolfgang Dahmen

On Oct 28, 2011, Prof. Wolfgang Dahmen delivered the second 2011 Gauss Lecture of the Deutsche Mathematiker Vereinigung. His lecture, entitled "Compressive Sensing - oder die Kunst der Abkürzung", was held at the Alte Mensa Forum, University of Mainz.
The Gauss Lectures are usually held twice a year. Speakers are invited as a special distinction, in recognition of their outstanding contributions to mathematics.

Prof. Alexander Mitsos wins poster award at the Planet XMap 2011

Former AICES Junior Research Group Leader Prof. Alexander Mitsos of the Massachusetts Institute of Technology, Mr. Ioannis N. Melas ,Mr. Dimitris E. Messinis, and Dr. Leonidas G. Alexopoulos of the National Technical University of Athens as well as Dr. Julio Saez-Rodriguez of the European Bioinformatics Institute are the winners of the poster award at the 2011 Planet XMap, that was held this year in Vienna. The title of their presentation was "Construction of large signaling pathways from phosphoproteomic data". This work was co-sponsored by AICES, Virtual Liver Network, and Rockwell International Career Development Professorship.

2011 Planet XMap, USA
October, 2011

Current Control Theory Must Be Revised for Biology, Study Finds

In a brief communication arising published Oct. 20 in Nature, Dr. F. J. Müller, CAU Kiel, and Prof. A. Schuppert at AICES, RWTH Aachen, show that today's established high-profile approaches (1) for systems control are severely limited in their generalization for the control of biological systems (2). This finding has direct implications for biomedical research and its current applications such as in the field of stem cell biology.
The German researchers propose that a future control theory for biology must cover self-regulation features of living cells resulting in a significant reduction of dimensionality observed in empirical data. These often underappreciated features of biology unfortunately cannot be sufficiently explained and utilized by the established control theory approaches. In their response to the points raised by Müller and Schuppert, the respected group around Albert-Lazlo Barabási states consequently on their general control theory: "our [previous] result hides subtleties that reveal as much about controllability as about the limits of our current understanding of biological networks" (3).
Schuppert explains: “In order to fully control a system—say for example a stem cell scientist wants to differentiate a stem cell into dopaminergic neurons, the type of cells, which are lost for example in Parkinson's Disease—the researcher ideally needs to ‘fully control’ the biological system. Following the current state-of-the-art control theory concepts, one would need to drive nearly all genes in such a process towards the desired cell population, something that’s basically impossible to do in reality.
"Evidence in the field and formalized by us, draws a completely different picture: We have very good reasons to believe, that only a few, cleverly chosen inputs can fully control and drive for example stem cells towards becoming the ‘perfect’ therapeutic agent. The key question is now, how can we find this ‘perfect linchpin’ for exerting full control over a biological system–and that’s what we are working on right now!"
This cutting edge type of research will be further pursued in a close collaboration between the systems biology expert Schuppert and the stem cell biologist Müller.

  • 1. Liu, Y.-Y., Slotine, J.-J. & Barabási, A.-L. Controllability of complex networks. Nature 473, 167–173 (2011).
  • 2. Müller, F.-J. & Schuppert, A. Few inputs can reprogram biological networks. Nature online (2011).doi:10.1038/nature10543
  • 3. Liu, Y.-Y., Slotine, J.-J. & Barabási, A.-L. Reply to Müller and Schuppert. Nature online (2011). doi:10.1038/nature10544

GREAT SUCCESS: AC.CES 2011 - Aachen Conference on Computational Engineering Science

With the "Wissenschaftspreis Weihenstephan der Stadt Freising", the scientists from Technical University of Munich (TUM) and RWTH Aachen University were awarded a prize of 12,000 euros for their joint research. The research team of Prof. Heiko Briesen, Chair for Process Systems Engineering at TUM (and a former AICES Young Researcher) and Prof. Marek Behr, Chair for Computational Analysis of Technical Systems at RWTH Aachen University, received the award for their collaborative work on "Structure Formation of Collodial Aggregates."
The two scientists found new ways to describe the multi-scale processes involving colloidal particles interacting with fluid flows by means of state-of-the-art simulation techniques and high-performance computers. The results enable the optimization of production processes in the food and pharmaceutical industry. The project is being carried out in the framework of the DFG focus program SPP 1273 "Colloidal Process Technology".

Location: Stadt Freising
Date: July 2011
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Science Prize of the City of Freising for Prof. Marek Behr and Prof. Heiko Briesen

With the "Wissenschaftspreis Weihenstephan der Stadt Freising", the scientists from Technical University of Munich (TUM) and RWTH Aachen University were awarded a prize of 12,000 euros for their joint research. The research team of Prof. Heiko Briesen, Chair for Process Systems Engineering at TUM (and a former AICES Young Researcher) and Prof. Marek Behr, Chair for Computational Analysis of Technical Systems at RWTH Aachen University, received the award for their collaborative work on "Structure Formation of Collodial Aggregates."
The two scientists found new ways to describe the multi-scale processes involving colloidal particles interacting with fluid flows by means of state-of-the-art simulation techniques and high-performance computers. The results enable the optimization of production processes in the food and pharmaceutical industry. The project is being carried out in the framework of the DFG focus program SPP 1273 "Colloidal Process Technology".

Location: Stadt Freising
Date: July 2011