Nature Cell Biology Paper on Feedback Loops in Murine Stem-Cells

AICES-researchers Bernhard Schuldt, Michael Lenz and Andreas Schuppert contributed to a new study investigating the effect of Nanog-dependent feedback loops in murine embryonic stem cells recently published on-line in Nature Cell Biology (doi:10.1038/ncb2603). The study was the result of an international cooperation of scientists from the University of Southampton, the Mount Sinai School of Medicine, the University of Kiel and the Schuppert group at AICES / RWTH Aachen. The AICES contribution extends prior work on pluripotency prediction (PMID:21378979, Nature Methods April 2011) to investigate the effect of a controlled perturbation in a small core pluritpotency network on global, whole genome scale gene expression.