Dr. Markus Krauß

Dr. Markus Krauß

Advisor / Co. Advisor

Prof. Schuppert

Dissertation

Coupling Genome-Scale Metabolic Networks with Whole-Body Pharmacokinetic Models for Multi-Scale Analysis of Network Perturbations

Contact

Markus Krauß, Dipl.-Ing.
Aachen Institute for Advanced Study
in Computational Engineering Science (AICES)
RWTH Aachen
Schinkelstr. 2
52062 Aachen

Phone: +49 (0) 214 30 47790
Email: krauss@aices.rwth-aachen.de

Education

11/2011 Doctoral student at Aachen Institute for Advanced Study in Computational Engineering Science (AICES), RWTH Aachen in affiliation with Bayer Technology Services, Leverkusen
10/2006 - 10/2011 Diploma in Biosystems-Engineering, Otto-von-Guericke University Magdeburg

Professional Career

03/2011 - 09/2011 Diploma student (Thesis: Coupling Genome-Scale Metabolic Networks with Whole-Body Pharmacokinetic Models for Multi-Scale Analysis of Network Perturbations), Bayer Technology Services, Leverkusen
04/2008 - 01/2010 Student assistant, Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg

Research Interests

Physiology-based Pharmacokinetic Modeling, Bayesian Modeling

Project Outline
Development, implementation and evaluation of a concept for the use of large mechanistic model kernels in the Bayesian analysis of time-dependent experimental data from biological and pharmacological experiments and trials

Publications

Krauss et al (2012) Integrating Cellular Metabolism into a Multiscale Whole-Body Model. PLoS Comput Biol 8: e1002750

featured in: Goodman C (2013) Metabolism: A model merger. Nat Chem Biol 9:9-9 Click here

featured in: Gelfand A (2013) Untangling Integrative Analysis. Biomedical Computation Review Click here

Krauss et al (2013) Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification. In Silico Pharmacology 1:6 Click here

Posters

Physiological modeling of inter-individual variability: Combining PBPK modeling and Markov-Chain-Monte-Carlo approaches, World Conference on Pharmacometrics (WCoP), 2012 Click here